From Airport Frankfurt am Main (FRA):
Train: 97 km directly from the trainstation at the airport to Fulda.
Prices from 15 € to 42€, depends on time of booking.
Please have a look here.
Fulda is also easy to reach by car, and if you’ve never experienced the Autobahn before, I’ll recommend that! 😉
(Please take care! Not too much seme!)